Description

Fmoc-D-Asp(2-Phenylisopropyl Ester)-Oh is a protected, enantiomerically pure derivative of aspartic acid, specifically designed for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the controlled introduction of the D-aspartic acid residue with a protected side chain, enabling the synthesis of complex and biologically active peptides. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid derivative for the automated synthesis of custom peptides.
• Pharmaceutical Research: For the development of novel peptide drugs, hormones, and enzyme inhibitors where D-amino acids are incorporated to enhance metabolic stability.
• Bioconjugation: Serving as a specialized linker or spacer molecule in the creation of peptide-protein or peptide-small molecule conjugates.
• Chemical Biology Probes: Used in the synthesis of labeled peptides for studying protein-protein interactions, enzyme activity, and cellular uptake mechanisms.
• Process Development: Employed in scaling up the production of therapeutic peptides under current Good Manufacturing Practice (cGMP) guidelines.

Basic Information

Product Name	Fmoc-D-Asp(2-Phenylisopropyl Ester)-Oh
CAS No.	214852-39-8
Molecular Formula	C₂₈H₂₇NO₆
Molecular Weight	473.52 g/mol
Synonyms	Fmoc-D-Asp(O-2-PhiPr)-OH; Fmoc-D-Aspartic acid 2-phenylisopropyl ester; N-(9-Fluorenylmethoxycarbonyl)-D-aspartic acid β-(2-phenyl-1-methylethyl) ester; Fmoc-D-Asp(OcHex)-OH (common analog); N-Fmoc-D-aspartic acid 4-(2-phenylpropan-2-yl) ester; Fmoc-D-Asp(OPip)-OH; D-Aspartic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 4-(2-phenyl-1-methylethyl) ester
EINECS	Contact for details

Quality Control

Every batch of Fmoc-D-Asp(2-Phenylisopropyl Ester)-Oh is manufactured and tested to meet stringent quality standards suitable for advanced research and pharmaceutical applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for purity, chiral integrity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.