Description

Fmoc-D-Arg(Boc)2-OH is a high-purity, orthogonally protected derivative of D-Arginine, a non-proteinogenic amino acid enantiomer. This compound is critically important as a key chiral building block in solid-phase peptide synthesis (SPPS), enabling the controlled introduction of D-arginine residues with precise stereochemistry. It is primarily required by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of novel peptide therapeutics, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected amino acid derivative for the automated synthesis of complex peptides containing D-arginine.
• Pharmaceutical Research: For the discovery and development of peptide-based drugs, including antimicrobial peptides (AMPs) and hormone analogs, where D-amino acids enhance metabolic stability.
• Bioconjugation & Probe Development: Serving as a precursor for creating labeled peptides or peptide-drug conjugates used in imaging and targeted therapies.
• Combinatorial Chemistry Libraries: Used to generate diverse peptide libraries for high-throughput screening against biological targets.
• Biochemical Research: For studying enzyme-substrate interactions, receptor binding, and the structure-activity relationships (SAR) of peptides.
• GMP Manufacturing: As a starting material or intermediate in the cGMP production of active pharmaceutical ingredients (APIs) for clinical trials.

Basic Information

Product Name	Fmoc-D-Arg(Boc)2-OH
CAS No.	214852-34-3
Molecular Formula	C32H43N5O8
Molecular Weight	625.72 g/mol
Synonyms	Fmoc-D-arginine(Boc)2-OH; Nα-Fmoc-Nω,ω'-bis(tert-butoxycarbonyl)-D-arginine; Fmoc-D-Arg(Boc2)-OH; (2R)-5-[[(2-Methylpropan-2-yl)oxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)pentyl]-(2-methylpropan-2-yl) carbamate; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-Nω,ω'-bis(tert-butoxycarbonyl)-D-arginine; D-Arg(Boc)2-Fmoc; Fmoc-D-Arg(Boc)-Boc-OH
EINECS	Contact for details

Quality Control

Our Fmoc-D-Arg(Boc)2-OH is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for sensitive peptide synthesis applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with research and pharmaceutical-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.