Description

2,4,6-Trifluorobenzyl Amine is a high-purity fluorinated aromatic amine building block of significant commercial and research interest. Its value lies in its role as a versatile synthon for introducing the 2,4,6-trifluorobenzyl moiety, which can enhance the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing advanced agrochemicals, active pharmaceutical ingredients (APIs), and specialty materials.

Application

• Pharmaceutical Intermediates: A key building block for the synthesis of novel drug candidates, particularly in areas like kinase inhibitors, antimicrobials, and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the fluorine atoms contribute to biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, altering their surface properties, chemical resistance, and durability.
• Cross-coupling Reactions: Acts as a valuable substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination) for creating complex aromatic amines.
• Chemical Research & Development: A crucial reagent for medicinal chemistry and process chemistry in both academic and industrial laboratories.

Basic Information

Product Name	2,4,6-Trifluorobenzyl Amine
CAS No.	214759-21-4
Molecular Formula	C7H6F3N
Molecular Weight	161.12 g/mol
Synonyms	(2,4,6-Trifluorophenyl)methanamine; 1-(Aminomethyl)-2,4,6-trifluorobenzene; 2,4,6-Trifluorobenzylamine; α-Amino-2,4,6-trifluorotoluene; 2,4,6-Trifluorobenzyl Amine Hydrochloride (salt form); TFBA
EINECS	Contact for details

Quality Control

Our 2,4,6-Trifluorobenzyl Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.