Description

Fmoc-D-Lys(Aloc)-Oh is a protected, non-natural amino acid derivative essential for advanced solid-phase peptide synthesis (SPPS). This compound matters because it provides orthogonal protection for the lysine side chain, enabling the precise, sequential construction of complex peptides and peptidomimetics. It is critically needed by research institutions and pharmaceutical companies developing therapeutic peptides, diagnostic agents, and biochemical tools where the D-configuration and specific side-chain deprotection are required.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled incorporation of D-lysine with an Aloc-protected side chain into peptide chains.
• Pharmaceutical Research & Development: Used in the synthesis of novel peptide-based drug candidates, including antimicrobial peptides and hormone analogs.
• Combinatorial Chemistry Libraries: Serves as a valuable component for creating diverse peptide libraries for high-throughput screening.
• Bioconjugation and Probe Development: Facilitates the site-specific attachment of labels, tags, or other molecules to peptides after selective deprotection.
• Academic Research: Employed in studies of peptide structure-activity relationships, protein folding, and enzyme-substrate interactions.

Basic Information

Product Name	Fmoc-D-Lys(Aloc)-Oh
CAS No.	214750-75-1
Molecular Formula	C25H28N2O6
Molecular Weight	452.50 g/mol
Synonyms	Fmoc-D-lysine(Aloc)-OH; N-α-Fmoc-N-ε-allyloxycarbonyl-D-lysine; Fmoc-D-Lys(Alloc)-OH; (2R)-6-{[(Prop-2-en-1-yloxy)carbonyl]amino}-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid; Fmoc-D-Lys(Aloc)-OH CAS NO 214750-75-1; Fmoc-D-Lys(Alloc)-OH; N-α-(9-Fluorenylmethoxycarbonyl)-N-ε-(allyloxycarbonyl)-D-lysine
EINECS	Contact for details

Quality Control

Our Fmoc-D-Lys(Aloc)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.