Description

Fmoc-D-Orn(Aloc)-OH is a protected, non-proteinogenic amino acid derivative, specifically the D-isomer of ornithine with orthogonal protecting groups. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of ornithine residues for advanced research and therapeutic peptide development. It is essential for researchers and manufacturers in pharmaceutical R&D, biotechnology, and fine chemical synthesis who require high-purity, stereochemically defined intermediates.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, facilitating the synthesis of complex peptides containing ornithine.
• Pharmaceutical Research: Used in the development of peptide-based drugs, antimicrobial peptides (AMPs), and hormone analogs where ornithine plays a structural or functional role.
• Bioconjugation and Linker Chemistry: The orthogonal Aloc (Allyloxycarbonyl) protecting group allows for selective deprotection in the presence of Fmoc, enabling sophisticated sequential modification and linker attachment strategies.
• Chemical Biology Probes: Serves as a precursor for labeled or modified amino acids used to study protein-protein interactions and enzyme mechanisms.
• Custom Peptide Service Providers: A fundamental reagent for CROs and CDMOs offering bespoke peptide manufacturing services.

Basic Information

Product Name	Fmoc-D-Orn(Aloc)-OH
CAS No.	214750-74-0
Molecular Formula	C₂₄H₂₆N₂O₆
Molecular Weight	438.48 g/mol
Synonyms	Fmoc-D-ornithine(Aloc)-OH; N-α-(9-Fluorenylmethoxycarbonyl)-N-δ-(allyloxycarbonyl)-D-ornithine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((allyloxy)carbonyl)amino)pentanoic acid; Fmoc-D-Orn(Alloc)-OH; N-δ-Alloc-N-α-Fmoc-D-ornithine; Fmoc-D-Lys(Aloc)-OH analog; D-Ornithine derivative, Fmoc- and Aloc-protected
EINECS	Contact for details

Quality Control

Our Fmoc-D-Orn(Aloc)-OH is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the stringent requirements of peptide synthesis. A Certificate of Analysis (COA) detailing purity, identity, and specific test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.