Description

(2S)-1-(9H-Fluoren-9-Ylmethoxycarbonyl)-2,3,3A,4,5,6,7,7A-Octahydroindole-2-Carboxylic Acid CAS NO 214750-71-7 is a high-purity, protected amino acid derivative, specifically an Fmoc-protected octahydroindole-2-carboxylic acid building block. This compound is critical for the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control and structural rigidity to the target molecule. It is an essential raw material for pharmaceutical R&D and production, particularly in the development of novel therapeutic agents and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the automated synthesis of complex peptides.
• Peptidomimetic Drug Discovery: Used to incorporate the constrained octahydroindole scaffold, which can improve metabolic stability and receptor binding affinity of drug candidates.
• Pharmaceutical Intermediate: Serves as a critical intermediate in the multi-step synthesis of active pharmaceutical ingredients (APIs) targeting neurological and metabolic disorders.
• Bioconjugation and Probe Development: Employed in the creation of labeled peptides for diagnostic imaging, biochemical assays, and targeted drug delivery systems.
• Academic and Industrial Research: A valuable reagent for medicinal chemistry programs exploring novel peptide-based structures in universities and contract research organizations (CROs).

Basic Information

Product Name	(2S)-1-(9H-Fluoren-9-Ylmethoxycarbonyl)-2,3,3A,4,5,6,7,7A-Octahydroindole-2-Carboxylic Acid
CAS No.	214750-71-7
Molecular Formula	C24H25NO4
Molecular Weight	391.46 g/mol
Synonyms	Fmoc-Octahydroindole-2-carboxylic acid; Fmoc-Oic-OH; (2S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]octahydro-1H-indole-2-carboxylic acid; 1-Fmoc-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid; Fmoc-D-Oic-OH (stereoisomer); Fmoc-protected 2-carboxyoctahydroindole; N-α-Fmoc-L-octahydroindole-2-carboxylic acid; Building block for peptidomimetics.
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality management systems to ensure batch-to-batch consistency for critical research and production applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each batch, confirming identity, purity, and chiral integrity. Our quality standards are designed to meet the stringent requirements of pharmaceutical R&D and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	[α]²⁰D = Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.