Description

Boc-p-Azido-D-Phe-Oh CAS NO 214630-05-4 is a protected amino acid derivative featuring a p-azidophenylalanine backbone with a tert-butoxycarbonyl (Boc) protecting group on the amine and a free carboxylic acid. This compound is a crucial building block in peptide synthesis and chemical biology, enabling the site-specific incorporation of an azide functional group for subsequent bioorthogonal conjugation via click chemistry. It is primarily utilized by pharmaceutical researchers, peptide chemists, and bioconjugation specialists for developing targeted therapeutics, diagnostic probes, and advanced biomaterials.

Application

• Peptide Synthesis: As a key intermediate for introducing azide handles into custom peptide sequences for downstream labeling or crosslinking.
• Chemical Biology & Bioconjugation: Enables site-specific modification of proteins, antibodies, and other biomolecules via strain-promoted azide-alkyne cycloaddition (SPAAC) or copper-catalyzed click chemistry (CuAAC).
• Drug Discovery: Used in the development of antibody-drug conjugates (ADCs), targeted drug delivery systems, and molecular imaging agents.
• Material Science: Functionalization of surfaces, polymers, and nanoparticles with bioactive peptides for creating smart biomaterials.
• Proteomics Research: Incorporation into activity-based probes (ABPs) for profiling enzyme activity or studying protein-protein interactions.
• Library Synthesis: Building block for combinatorial libraries of azide-containing compounds for high-throughput screening.

Basic Information

Product Name	Boc-p-Azido-D-Phe-Oh
CAS No.	214630-05-4
Molecular Formula	C₁₄H₁₈N₄O₄
Molecular Weight	306.32 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-4-azido-D-phenylalanine; Boc-4-Azido-D-Phe-OH; (R)-2-((tert-Butoxycarbonyl)amino)-3-(4-azidophenyl)propanoic acid; Boc-D-Phe(4-N3)-OH; N-Boc-4-azido-D-phenylalanine; tert-Butyl (R)-(1-(4-azidophenyl)-3-carboxy-3-oxopropyl)carbamate; p-Azido-D-phenylalanine, N-Boc-protected
EINECS	Contact for details

Quality Control

Our Boc-p-Azido-D-Phe-Oh is manufactured under strict quality protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure compliance with research and pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under inert atmosphere for long-term stability. The compound is light-sensitive and should be handled under appropriate conditions to prevent degradation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0% (Area %)
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.