Description

Boc-D-Arg(Pmc)-OH is a protected derivative of the non-natural D-isomer of the amino acid arginine, widely used as a critical building block in peptide synthesis. This compound is essential for researchers and manufacturers requiring high-purity, enantiomerically pure intermediates to construct complex peptide sequences with specific chiral centers. It is primarily utilized by the pharmaceutical, biotechnology, and research sectors for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of D-arginine residues into peptide chains, enabling the creation of metabolically stable analogs.
• Pharmaceutical Research: Used in the R&D of novel peptide-based drugs, including hormone analogs, enzyme inhibitors, and antimicrobial peptides.
• Bioconjugation: Serves as a precursor for labeling peptides with probes or linkers, useful in diagnostic imaging and targeted drug delivery systems.
• Process Development: Employed in scaling up the production of peptide active pharmaceutical ingredients (APIs) under current Good Manufacturing Practice (cGMP) guidelines.
• Biochemical Tool Development: Integral for synthesizing custom peptides used as substrates, inhibitors, or standards in enzymatic assays and analytical methods.

Basic Information

Product Name	Boc-D-Arg(Pmc)-OH
CAS No.	214630-02-1
Molecular Formula	C24H39N5O6S
Molecular Weight	525.67 g/mol
Synonyms	Nα-Boc-Nω-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-D-arginine; Boc-D-arginine(Pmc)-OH; tert-Butyloxycarbonyl-D-arginine(Pentamethylchroman-6-sulfonyl)-OH; Boc-D-Arg(Pbf)-OH (common alternate abbreviation); (2S)-5-[[(2,2,5,7,8-Pentamethyl-3,4-dihydro-2H-chromen-6-yl)sulfonyl]amino]-2-[[(2-methylpropan-2-yl)oxycarbonyl]amino]pentanoic acid; D-Boc-Arg(Pmc)-OH; N-Boc-N'-Pmc-D-arginine
EINECS	Contact for details

Quality Control

Our Boc-D-Arg(Pmc)-OH is manufactured under stringent quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and cGMP applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific pharmacopeial (e.g., USP) or custom requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.5%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.