Description

Ethanone, 1-(2-Amino-5-Fluorophenyl)-2,2,2-Trifluoro- (9Ci) is a high-purity trifluoromethyl ketone derivative, serving as a critical advanced pharmaceutical intermediate (API intermediate). Its core value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine and ketone functionalities into target molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Fluorinated Compound Research: Serves as a precursor for introducing the -COCF3 moiety into more complex fluorinated organic molecules in academic and industrial R&D settings.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands and organocatalysts for asymmetric synthesis and other catalytic processes.
• Material Science Precursor: Potential use in the synthesis of monomers or additives for specialty polymers with unique optical or surface properties.

Basic Information

Product Name	Ethanone, 1-(2-Amino-5-Fluorophenyl)-2,2,2-Trifluoro- (9Ci)
CAS No.	214288-07-0
Molecular Formula	C9H7F4NO
Molecular Weight	221.15 g/mol
Synonyms	2-Amino-5-fluoro-α,α,α-trifluoroacetophenone; 1-(2-Amino-5-fluorophenyl)-2,2,2-trifluoroethanone; 2-Amino-α,α,α-trifluoro-5-fluoroacetophenone; 5-Fluoro-2-amino-α,α,α-trifluoroacetophenone; 2-Amino-5-fluorophenyl trifluoromethyl ketone; 2'-Amino-5'-fluoro-2,2,2-trifluoroacetophenone; (2-Amino-5-fluorophenyl)(trifluoromethyl)methanone
EINECS	Contact for details

Quality Control

Our Ethanone, 1-(2-Amino-5-Fluorophenyl)-2,2,2-Trifluoro- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from heat, sparks, and open flame. For long-term storage, consider storage under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.