Description

(4S)-6-Chloro-4-(2-Cyclopropylethynyl)-4-(Trifluoromethyl)-3,4-Dihydroquinazolin-2(1H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its chiral center and complex heterocyclic structure. This compound is of significant value in modern medicinal chemistry for the research and development of novel therapeutic agents, particularly due to the presence of the trifluoromethyl group which is known to enhance metabolic stability and bioavailability. It is primarily sought by R&D laboratories and pharmaceutical manufacturers engaged in the synthesis of targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of investigational new drugs (INDs) and new chemical entities (NCEs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop compounds with improved efficacy.
• API Development: Serves as a critical precursor in the development and scale-up of active pharmaceutical ingredients (APIs) for clinical trials.
• Protease Inhibitor Synthesis: Potential application in the synthesis of inhibitors targeting specific enzymes, given the quinazolinone core structure.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying biological pathways and target engagement.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific custom synthesis projects.

Basic Information

Item	Information
Product Name	(4S)-6-Chloro-4-(2-Cyclopropylethynyl)-4-(Trifluoromethyl)-3,4-Dihydroquinazolin-2(1H)-One
CAS No.	214287-88-4
Molecular Formula	C14H10ClF3N2O
Molecular Weight	314.69 g/mol
Synonyms	(4S)-6-Chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydroquinazolin-2(3H)-one; (4S)-6-Chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-3,4-dihydro-2(1H)-quinazolinone; 214287-88-4; (S)-6-Chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one; 6-Chloro-4-[(1S)-2-cyclopropylethynyl-1-(trifluoromethyl)]-3,4-dihydro-2(1H)-quinazolinone
EINECS	Contact for details

Quality Control

Our (4S)-6-Chloro-4-(2-Cyclopropylethynyl)-4-(Trifluoromethyl)-3,4-Dihydroquinazolin-2(1H)-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes rigorous analytical testing, including chiral purity verification by HPLC. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.