Description

Biotinyl-Neuropeptide Y (Human, Rat) is a biotin-conjugated analog of the potent neuropeptide Y (NPY), a key regulatory peptide involved in numerous physiological processes. This modified peptide is essential for advanced biochemical research, enabling highly sensitive detection and isolation techniques through its strong affinity for streptavidin or avidin. It is primarily utilized by researchers in neuroscience, endocrinology, and pharmacology for applications such as receptor binding studies, immunohistochemistry, and signal transduction pathway analysis. The compound, identified by CAS NO 213779-13-6, represents a critical tool for elucidating the complex roles of NPY in energy balance, stress response, and cardiovascular function.

Application

• Receptor Binding & Competition Assays: Used as a labeled ligand to study NPY receptor (Y1, Y2, Y4, Y5) affinity, distribution, and kinetics.
• Immunohistochemistry & Microscopy: Enables visualization and localization of NPY receptors in tissue sections via streptavidin-biotin complex amplification.
• Affinity Purification & Pull-Down Assays: Facilitates the isolation and characterization of NPY receptor proteins and associated signaling complexes.
• Biosensor Development: Serves as a capture probe in surface plasmon resonance (SPR) or other label-free detection systems for real-time interaction analysis.
• Signal Transduction Research: Aids in investigating downstream effects of NPY receptor activation on cellular pathways.
• Drug Discovery Screening: Employed in high-throughput screening platforms to identify novel agonists or antagonists targeting NPY receptors.

Basic Information

Product Name	Biotinyl-Neuropeptide Y (Human, Rat)
CAS No.	213779-13-6
Molecular Formula	C192H290N56O57S
Molecular Weight	~4251.8 g/mol
Synonyms	Biotin-NPY; Biotinylated Neuropeptide Y; Biotin-Neuropeptide Y (human, rat); NPY-Biotin; Biotinyl-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Leu-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2; Biotinylated NPY (1-36); [Biotinyl]Neuropeptide Y
EINECS	Contact for details

Quality Control

Our Biotinyl-Neuropeptide Y (Human, Rat) is produced under stringent conditions to ensure the highest standards of purity and biological activity. Each batch undergoes comprehensive analytical characterization, including reverse-phase HPLC for purity assessment and mass spectrometry (MS) for identity confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data on purity, peptide content, and solubility. Our quality system is designed to meet the rigorous demands of pharmaceutical and academic research, ensuring reliable and reproducible results for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive). For long-term stability, store desiccated at -20°C or below. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. Aliquot into single-use quantities to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Retention time and mass conform to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical composition
Solubility	Soluble in water, dilute acetic acid, or DMSO
Biological Activity	Confirmed by receptor binding assay (Data on COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.