Description

(Tyr36)-Pth-Related Protein (1-36) (Human, Mouse, Rat) is a synthetic peptide fragment of the parathyroid hormone-related protein (PTHrP), a critical regulator of calcium homeostasis and bone metabolism. This high-purity research-grade peptide is essential for advancing studies in endocrinology, oncology, and skeletal biology. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in metabolic disease research, cancer studies, and drug discovery programs.

Application

• Biomedical Research: Fundamental research into the physiological and pathological roles of PTHrP in calcium regulation and bone development.
• Drug Discovery & Development: Serving as a reference standard, competitive ligand, or lead compound in screening assays for osteoporosis and hypercalcemia of malignancy treatments.
• Receptor Binding Studies: Investigating interactions with the PTH/PTHrP type 1 receptor (PTH1R) to elucidate signaling pathways and receptor activation mechanisms.
• Cell Culture & In Vitro Assays: Used to stimulate cellular responses in osteoblast, chondrocyte, or cancer cell line models to study proliferation, differentiation, and gene expression.
• Antibody Production & Immunoassays: Acting as an immunogen for generating specific antibodies or as a calibrator/control in ELISA and other immunoassay development.
• Signal Transduction Research: Probing downstream cAMP and protein kinase A (PKA) signaling cascades activated by PTHrP fragment binding.

Basic Information

Product Name	(Tyr36)-Pth-Related Protein (1-36) (Human, Mouse, Rat)
CAS No.	213779-11-4
Molecular Formula	C₁₈₀H₂₈₈N₅₄O₅₅S₂
Molecular Weight	4108.7 g/mol
Synonyms	PTHrP (1-36), Tyr36-PTHrP(1-36); Parathyroid Hormone-Related Protein (1-36), human; PTHLH (1-36); [Tyr36]-PTHrP(1-36) amide; Hypercalcemia of malignancy factor (1-36); Osteostatin precursor fragment; PTH-related peptide fragment 1-36; PTHRP (1-36)
EINECS	Contact for details

Quality Control

Our synthetic peptides are manufactured under stringent quality systems. Each batch of (Tyr36)-PTHrP (1-36) undergoes comprehensive analytical characterization to ensure identity, purity, and biological activity. Quality is verified by multiple orthogonal methods including HPLC, MS, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided with every shipment to support your research compliance and reproducibility requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to minimize freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Consistent with reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Composition	Within ±10% of theoretical
Molecular Weight (MS)	4108.7 ± 2 Da
Solubility	Soluble in water or dilute acetic acid
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.