Description

(Tyr1)-Pth (1-34) (Human) CAS NO 213779-10-3 is a synthetic peptide fragment of human parathyroid hormone, specifically the biologically active N-terminal region. This high-purity peptide is a critical research tool for studying calcium and phosphate metabolism, bone remodeling, and renal function. It is essential for pharmaceutical R&D, academic research in endocrinology, and as a reference standard in bioanalytical method development.

Application

• Biomedical Research: Fundamental studies on the mechanism of action of parathyroid hormone (PTH) and its role in calcium homeostasis.
• Drug Discovery & Development: Used as a reference compound and pharmacological tool in the screening and development of novel therapeutics for osteoporosis and hyperparathyroidism.
• Bioassay Standard: Serves as a calibrated reference standard in cell-based assays (e.g., cAMP stimulation assays) and receptor binding studies to quantify biological activity.
• Metabolic Studies: Investigation of PTH's effects on bone formation/resorption and kidney function in preclinical models.
• Quality Control: Employed as a system suitability standard in analytical methods (e.g., HPLC, LC-MS) for related peptide pharmaceuticals.
• Antibody Production: Can be used as an immunogen or antigen for generating and characterizing specific antibodies against PTH.

Basic Information

Product Name	(Tyr1)-Pth (1-34) (Human)
CAS No.	213779-10-3
Molecular Formula	C181H291N55O51S2
Molecular Weight	4117.7 g/mol
Synonyms	[Tyr1]-PTH (1-34) (human); [Tyr1]-Parathyroid Hormone (1-34), human; H-Tyr-Ser-Val-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH; PTH (1-34) (human) Tyr1 analog; Parathyroid Hormone Fragment (1-34), [Tyr1]-; Human PTH (1-34) with N-terminal Tyrosine
EINECS	Contact for details

Quality Control

Our (Tyr1)-Pth (1-34) (Human) is manufactured under stringent conditions to ensure the highest standards of purity and biological activity. Each batch is subjected to comprehensive analytical testing including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass consistent with theoretical molecular weight
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by AAA)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Biological Activity	Assessed by in vitro cAMP stimulation assay (COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.