Description

2-Propenal,3-(4-Fluorophenyl)-,(2Z)-(9Ci) is a specialized fluorinated organic building block with the CAS registry number 213617-57-3. This compound is valued for its unique molecular structure, which incorporates both an α,β-unsaturated aldehyde moiety and a fluorinated aromatic ring, making it a versatile intermediate in advanced synthetic chemistry. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical sectors for constructing complex molecules where the introduction of fluorine atoms and specific stereochemistry is critical for modulating biological activity, metabolic stability, and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, anti-inflammatory agents, and CNS-targeted drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorophenyl group enhances lipophilicity and target binding.
• Material Science Research: Serves as a monomer or precursor for specialty polymers and liquid crystals, leveraging its rigid, fluorinated structure to influence material properties.
• Chemical Biology Probes: Employed in the synthesis of fluorescent tags, affinity labels, and other molecular probes for studying biological systems.
• Asymmetric Catalysis Substrate: Utilized in methodological development for stereoselective reactions, such as conjugate additions and cycloadditions, due to its defined (Z)-configuration.
• Fine Chemical Manufacturing: Acts as a building block for complex fragrance and flavor molecules, where specific stereochemistry is essential.

Basic Information

Product Name	2-Propenal,3-(4-Fluorophenyl)-,(2Z)-(9Ci)
CAS No.	213617-57-3
Molecular Formula	C9H7FO
Molecular Weight	150.15 g/mol
Synonyms	(2Z)-3-(4-Fluorophenyl)prop-2-enal; (Z)-3-(4-Fluorophenyl)acrylaldehyde; (Z)-4-Fluorocinnamaldehyde; 3-(4-Fluorophenyl)-2-propenal, (Z)-; 2-Propenal, 3-(4-fluorophenyl)-, (2Z)-; (Z)-3-(p-Fluorophenyl)acrolein; (2Z)-3-(4-Fluorophenyl)acrylaldehyde
EINECS	Contact for details

Quality Control

Our production of 2-Propenal,3-(4-Fluorophenyl)-,(2Z)-(9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, isomeric composition, and impurity profiles. We employ advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy to verify identity and confirm the critical (Z)-stereochemistry. Our quality system is designed to meet the exacting standards of GMP environments for non-clinical and early-phase development work.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This compound is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and purity. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95.0% (Area %)
Isomeric Purity ((Z)-isomer)	≥ 98.0% (by HPLC)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.