Description

(D-Tyr4)-Mtii is a potent and selective peptide antagonist for the melanocortin receptor subtype 4 (MC4R). This compound is a critical research tool for studying energy homeostasis, feeding behavior, and related metabolic pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neuroscience, endocrinology, and obesity-related drug discovery programs.

Application

• Neuroscience Research: Used as a selective MC4R antagonist to investigate its role in appetite regulation, energy balance, and body weight control.
• Pharmacological Studies: Serves as a reference standard in receptor binding assays and functional studies to characterize new melanocortin receptor ligands.
• Drug Discovery & Development: A key compound for screening and validating potential therapeutics targeting metabolic disorders such as obesity and cachexia.
• Academic & Institutional Research: Employed in university and research institute labs for fundamental studies on the melanocortin system and its physiological functions.
• Biochemical Assay Development: Utilized in the development and validation of high-throughput screening (HTS) assays for MC4R activity.
• Preclinical Animal Studies: Administered in vivo to establish proof-of-concept for MC4R-targeted interventions in animal models of metabolic disease.

Basic Information

Product Name	(D-Tyr4)-Mtii
CAS No.	213314-49-9
Molecular Formula	C₄₆H₆₈N₁₄O₁₀
Molecular Weight	977.1 g/mol
Synonyms	Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂; SHU-9119; (D-Tyr4)-Melanotan II; (D-Tyr4)-MTII; Ac-Nle-cyclo[Asp-His-D-Tyr-Arg-Trp-Lys]-NH₂; Melanocortin 4 Receptor Antagonist (D-Tyr4)-MTII; MC4R Antagonist (D-Tyr4)-MTII
EINECS	Contact for details

Quality Control

Our (D-Tyr4)-Mtii is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, identity, and other critical parameters are available upon request to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95%
Single Impurity (HPLC)	≤1.0%
Water Content (KF)	≤5.0%
Peptide Content	≥80%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.