Description

4,6-Dichloro-5-Fluoropyrimidine is a high-purity fluorinated pyrimidine derivative, a crucial building block in modern synthetic chemistry. Its value lies in its unique halogenated structure, which enables precise molecular modifications essential for developing advanced materials and active pharmaceutical ingredients (APIs). This intermediate is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for synthesizing novel compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of antiviral, anticancer, and other biologically active molecules, particularly in nucleoside and nucleotide analog synthesis.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging its fluoropyrimidine core.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Material Science Precursor: Employed in the synthesis of specialized polymers, liquid crystals, and electronic materials requiring fluorinated heterocycles.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up production under cGMP or ISO standards.

Basic Information

Product Name	4,6-Dichloro-5-Fluoropyrimidine
CAS No.	213265-83-9
Molecular Formula	C4HCl2FN2
Molecular Weight	166.97 g/mol
Synonyms	5-Fluoro-4,6-dichloropyrimidine; 4,6-Dichloro-5-fluoropyrimidine; 5-Fluoropyrimidine-4,6-dichloride; 4,6-Dichloro-5-fluoro-1,3-diazine; NSC 405124; Dichlorofluoropyrimidine; Fluorodichloropyrimidine
EINECS	Contact for details

Quality Control

Our 4,6-Dichloro-5-Fluoropyrimidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to relevant ISO guidelines, and we support development under cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.