Description

H-Thr-Arg-Pro-Ile-Ile-Thr-Thr-m-Nitro-Tyr-Gly-Pro-Ser-Asp-Lys(Abz)-Tyr-Oh is a synthetic peptide sequence of significant interest in advanced biochemical research and pharmaceutical development. This compound, with CAS number 213135-91-2, serves as a critical tool for studying protease activity, enzyme kinetics, and signal transduction pathways. It is primarily utilized by research institutions, diagnostic developers, and biopharmaceutical companies engaged in the discovery of novel therapeutic agents and diagnostic assays.

Application

• Protease Substrate Research: Used as a specific, fluorogenic substrate for studying the activity and inhibition of various proteolytic enzymes.
• Biochemical Assay Development: A key component in the design and validation of high-throughput screening (HTS) assays for drug discovery programs.
• Enzyme Kinetics Studies: Employed to determine kinetic parameters (Km, Vmax, kcat) and elucidate the mechanism of action of target enzymes.
• Diagnostic Reagent Manufacturing: Incorporated into diagnostic kits for the detection and quantification of specific enzyme biomarkers in clinical samples.
• Cell Signaling Pathway Analysis: Utilized to probe and modulate intracellular signaling cascades in cell-based research models.
• Pharmaceutical Intermediate: Serves as a building block or a reference standard in the synthesis and quality control of peptide-based therapeutics.

Basic Information

Product Name	H-Thr-Arg-Pro-Ile-Ile-Thr-Thr-m-Nitro-Tyr-Gly-Pro-Ser-Asp-Lys(Abz)-Tyr-Oh
CAS No.	213135-91-2
Molecular Formula	C86H124N22O26
Molecular Weight	1841.99 g/mol
Synonyms	Abz-Thr-Arg-Pro-Ile-Ile-Thr-Thr-Tyr(3-NO2)-Gly-Pro-Ser-Asp-Lys-Tyr-OH; Fluorogenic Peptide Substrate 213135-91-2; H-Thr-Arg-Pro-Ile-Ile-Thr-Thr-Tyr(3-Nitro)-Gly-Pro-Ser-Asp-Lys(Abz)-Tyr-OH; 2-Aminobenzoyl-Thr-Arg-Pro-Ile-Ile-Thr-Thr-Tyr(3-NO2)-Gly-Pro-Ser-Asp-Lys-Tyr-OH; Peptide for Protease Assay; CAS 213135-91-2; m-Nitro-Tyr containing peptide substrate; Abz/Dnp based quenched fluorescent peptide.
EINECS	Contact for details

Quality Control

Our peptide products are manufactured under strict quality management systems. Each batch of H-Thr-Arg-Pro-Ile-Ile-Thr-Thr-m-Nitro-Tyr-Gly-Pro-Ser-Asp-Lys(Abz)-Tyr-Oh undergoes comprehensive analytical characterization, including HPLC for purity and MS for identity confirmation, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO, or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.