Description

[Phe1-Psi(Ch2-Nh)Gly2]Nociceptin(1-13)NH2 is a synthetic, pseudopeptide analog of the endogenous neuropeptide nociceptin/orphanin FQ (N/OFQ). This compound is specifically engineered with a reduced peptide bond (psi) to enhance metabolic stability and receptor selectivity, making it a critical tool for advanced neuroscience and pharmacological research. It is primarily utilized by research institutions and pharmaceutical R&D departments focused on studying the NOP (nociceptin opioid peptide) receptor system, pain modulation, anxiety, and addiction pathways.

Application

• Neuroscience Research: A key ligand for investigating the structure, function, and signaling pathways of the NOP (ORL-1) receptor.
• Pharmacological Studies: Used in in vitro and in vivo assays to study nociceptin's role in pain perception, analgesia, and tolerance development.
• Drug Discovery & Development: Serves as a reference standard and lead compound for developing novel therapeutics targeting pain, anxiety, depression, and substance use disorders.
• Biochemical Assays: Employed in receptor binding studies, functional cAMP assays, and GTPγS binding experiments to characterize agonist/antagonist activity.
• Metabolic Stability Research: The pseudopeptide modification makes it a model compound for studying peptide stability and bioavailability.

Basic Information

Product Name	[Phe1-Psi(Ch2-Nh)Gly2]Nociceptin(1-13)NH2
CAS No.	213130-17-7
Molecular Formula	C75H111N21O16
Molecular Weight	1550.83 g/mol
Synonyms	[Phe¹ψ(CH₂NH)Gly²]Nociceptin(1-13)NH₂; Nociceptin (1-13), [Phe¹ψ(CH₂NH)Gly²]-; Pseudonociceptin(1-13)amide; (Phe¹-ψ(CH₂-NH)-Gly²)-Nociceptin(1-13)-NH₂; N/OFQ(1-13) analog, reduced bond; ORL-1 receptor agonist analog; Nociceptin pseudopeptide; F/G Nociceptin Fragment (1-13) analog
EINECS	Contact for details

Quality Control

Our [Phe1-Psi(Ch2-Nh)Gly2]Nociceptin(1-13)NH2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Our quality commitment supports reproducible and reliable scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.