Description

Nocistatin (Human) CAS NO 212609-11-5 is a bioactive peptide known for its role as a specific antagonist of nociceptin/orphanin FQ (N/OFQ) signaling. This compound is crucial for advanced neuroscience and pharmacological research, enabling the precise study of the N/OFQ receptor (NOP) system and its implications in pain modulation, anxiety, and addiction. It is an essential tool for researchers and developers in the pharmaceutical, biotechnology, and academic sectors focused on neuropeptide pathways and central nervous system drug discovery.

Application

• Neuroscience Research: Fundamental tool for investigating the physiological and pathological roles of the nociceptin/orphanin FQ (N/OFQ) peptide system.
• Pain Mechanism Studies: Used to antagonize NOP receptor activity in models to study pain transmission, analgesia, and hyperalgesia.
• Psychopharmacology: Critical for research into anxiety, depression, stress responses, and reward pathways influenced by the N/OFQ system.
• Drug Discovery & Development: Serves as a reference standard and pharmacological probe in screening assays for novel NOP receptor-targeted therapeutics.
• Academic & Institutional Research: Supports basic science in universities and research institutes studying G-protein coupled receptors (GPCRs) and neuropeptides.
• Biomarker Research: Potential use in studies correlating N/OFQ system activity with specific neurological conditions or states.

Basic Information

Product Name	Nocistatin (Human)
CAS No.	212609-11-5
Molecular Formula	C85H138N24O26S
Molecular Weight	1896.2 g/mol
Synonyms	Human Nocistatin; Nocistatin (1-17), human; NST; Nocistatin Peptide; Nocistatin-17; Nocistatin-17, human; Nocistatin (human, bovine, mouse, rat); [Asn17]-Nocistatin (human); Nocistatin (1-17) amide, human
EINECS	Contact for details

Quality Control

Our Nocistatin (Human) is produced under stringent conditions to ensure the highest standards of purity and biological activity, suitable for sensitive research applications. Each batch is supported by comprehensive analytical data. Certificates of Analysis (COA) detailing purity, peptide content, and sterility (where applicable) are available upon request, ensuring full traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Biological Activity	Confirmed by functional assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.