Description

Benserazide CAS NO 212579-80-1 is a potent peripheral aromatic L-amino acid decarboxylase (AADC) inhibitor. It is a critical pharmaceutical intermediate, primarily used in combination with levodopa for the treatment of Parkinson's disease. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical sectors developing advanced neurological therapies.

Application

• Pharmaceutical Active Ingredient: Key component in combination therapies for Parkinson's disease, where it inhibits the peripheral metabolism of levodopa, enhancing its central nervous system bioavailability.
• Neurological Research: Used as a research chemical in preclinical and clinical studies to investigate dopaminergic pathways, enzyme inhibition, and treatment mechanisms for movement disorders.
• Fine Chemical Synthesis: Serves as a sophisticated building block for the synthesis of more complex molecules targeting decarboxylase enzymes.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development, validation, and assay of pharmaceutical formulations.
• API Manufacturing: Integral raw material in the production of finished dosage forms, such as tablets and capsules, containing levodopa/benserazide combinations.

Basic Information

Product Name	Benserazide
CAS No.	212579-80-1
Molecular Formula	C10H15N3O5
Molecular Weight	257.24 g/mol
Synonyms	Benserazide Hydrochloride (common salt form); DL-Serine 2-(2,3,4-trihydroxybenzyl)hydrazide; Ro 4-4602; L-Aromatic amino acid decarboxylase inhibitor; NSC 113393; (RS)-Benserazide; 2-[(2,3,4-Trihydroxyphenyl)methyl]hydrazinyl]-3-hydroxypropanoic acid
EINECS	Contact for details

Quality Control

Our Benserazide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by IR and NMR spectroscopy, to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) with detailed batch-specific results are provided to guarantee traceability and compliance with relevant guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.