Description

Boc-Glu(Oal)-Oal is a protected amino acid derivative, specifically a glutamate analog with both the α-carboxyl and side-chain carboxyl groups esterified as allyl esters and the α-amino group protected by a tert-butyloxycarbonyl (Boc) group. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), enabling the controlled and sequential assembly of complex peptides. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries for the development of novel therapeutic peptides and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of glutamic acid residues into peptide chains.
• Pharmaceutical Research: Used in the research and development of peptide-based drugs, hormones, and vaccines.
• Bioconjugation: Serves as a precursor for creating peptide conjugates with other molecules like drugs, dyes, or polymers.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Biochemical Probe Development: Used to synthesize labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• Custom Peptide Manufacturing: An essential raw material for CROs and CDMOs producing custom peptides at various scales.

Basic Information

Product Name	Boc-Glu(Oal)-Oal
CAS No.	212569-21-6
Molecular Formula	C₁₇H₂₇NO₆
Molecular Weight	341.40 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-glutamic acid α,γ-diallyl ester; Boc-L-glutamic acid diallyl ester; (2S)-2-[(tert-Butoxycarbonyl)amino]pentanedioic acid 1,5-diallyl ester; Boc-Glu(OAllyl)-OAllyl; Boc-Glu(OAll)-OAll; N-Boc-L-glutamic acid diallyl ester; L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 1,5-diallyl ester
EINECS	Contact for details

Quality Control

Our Boc-Glu(Oal)-Oal is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.