Description

N6-Fmoc-D-Lysine is a protected, non-natural amino acid derivative essential for solid-phase peptide synthesis (SPPS). This high-purity building block is critical for researchers and manufacturers developing complex peptides and peptidomimetics with precise stereochemistry. It is primarily utilized in pharmaceutical R&D, biotechnology, and advanced materials science for creating novel therapeutic candidates and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected D-amino acid building block for the automated synthesis of peptides containing D-lysine residues.
• Pharmaceutical Research: Used in the development of peptide-based drugs, including antimicrobial peptides, hormone analogs, and targeted therapeutics where D-amino acids enhance metabolic stability.
• Bioconjugation & Linker Chemistry: The side-chain Fmoc protection and free α-amino/α-carboxyl groups allow for selective deprotection and conjugation strategies.
• Combinatorial Chemistry Libraries: Serves as a chiral scaffold for generating diverse libraries of compounds for high-throughput screening in drug discovery.
• Synthesis of Peptidomimetics: Integral for creating modified peptide structures with improved pharmacological properties.
• Biochemical Research: Employed in studies of enzyme specificity, protein-protein interactions, and structure-activity relationships (SAR).

Basic Information

Product Name	N6-Fmoc-D-Lysine
CAS No.	212140-39-1
Molecular Formula	C22H26N2O4
Molecular Weight	382.46 g/mol
Synonyms	Fmoc-D-Lys-OH; N-α-Fmoc-N-ε-Fmoc-D-lysine; D-Lysine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)hexanoic acid; Fmoc-D-Lys(Fmoc)-OH; Nε-Fmoc-D-lysine; N6-Fmoc-D-lysine; Boc-D-Lys(Fmoc)-OH (related, different protection)
EINECS	Contact for details

Quality Control

Our N6-Fmoc-D-Lysine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis, to ensure compliance with high-grade research and cGMP starting material standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98%), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.