Description

Fmoc-D,L-α-Amino-2-Thiophenacetic Acid is a protected amino acid derivative crucial for solid-phase peptide synthesis (SPPS). This compound matters as it serves as a key building block for introducing the unique structural and electronic properties of the thiophene moiety into synthetic peptides and peptidomimetics. Pharmaceutical researchers and fine chemical manufacturers need it for developing novel therapeutic agents, chemical probes, and advanced materials where the heterocyclic thiophene ring can modulate bioactivity, stability, and binding characteristics.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary use as an Fmoc-protected amino acid for the automated synthesis of peptide chains containing thiophene-based unnatural amino acids.
• Pharmaceutical Intermediate: Critical building block in the research and development of novel drug candidates, particularly in oncology, neurology, and antimicrobial therapies.
• Peptidomimetic Design: Enables the creation of peptide-like molecules with enhanced metabolic stability and receptor selectivity by incorporating the thiophene heterocycle.
• Chemical Biology & Proteomics: Used to synthesize labeled peptides or activity-based probes for studying protein function and interactions.
• Material Science Research: Incorporation into functional polymers or self-assembling peptides for advanced material applications.
• Academic & Contract Research: Essential reagent for universities and CROs conducting cutting-edge research in organic chemistry and medicinal chemistry.

Basic Information

Product Name	Fmoc-D,L-α-Amino-2-Thiophenacetic Acid
CAS No.	211682-11-0
Molecular Formula	C₂₁H₁₇NO₄S
Molecular Weight	379.43 g/mol
Synonyms	Fmoc-2-Thienylglycine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-thienylglycine; Fmoc-Thg-OH; Fmoc-DL-2-Thienylglycine; N-Fmoc-2-thienylglycine; (RS)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-2-thiophen-2-ylacetic acid; 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-thiophen-2-ylacetic acid
EINECS	Contact for details

Quality Control

Our Fmoc-D,L-α-Amino-2-Thiophenacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for peptide synthesis and pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, chiral composition, and residual solvent levels is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Composition (DL Ratio)	~50:50 (Racemic)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.