Description

(E)-Ethyl 3-(4-Amino-2-(Methylthio)Pyrimidin-5-Yl)Acrylate is a high-purity, functionalized pyrimidine derivative serving as a critical building block in advanced organic synthesis. This compound is essential for research and development in medicinal chemistry, enabling the construction of complex heterocyclic scaffolds. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of nucleoside analogs, kinase inhibitors, and other small molecule drug candidates.
• Agrochemical Research: Used in developing novel fungicides and herbicides that target specific biological pathways.
• Chemical Biology: Serves as a precursor for labeled probes and molecular tools used in biochemical assays and diagnostic research.
• Material Science: Investigated as a monomer or functional component in the development of specialty polymers and advanced organic materials.
• Academic & Contract Research: Employed in university and CRO laboratories for method development and exploratory synthesis projects.

Basic Information

Product Name	(E)-Ethyl 3-(4-Amino-2-(Methylthio)Pyrimidin-5-Yl)Acrylate
CAS No.	211244-80-3
Molecular Formula	C10H13N3O2S
Molecular Weight	239.29 g/mol
Synonyms	Ethyl (2E)-3-(4-Amino-2-methylsulfanylpyrimidin-5-yl)prop-2-enoate; 2-Propenoic acid, 3-(4-amino-2-(methylthio)-5-pyrimidinyl)-, ethyl ester, (E)-; Ethyl (E)-3-(4-Amino-2-(methylthio)pyrimidin-5-yl)acrylate; 5-[(1E)-3-Ethoxy-3-oxoprop-1-en-1-yl]-2-(methylsulfanyl)pyrimidin-4-amine; (E)-Ethyl 3-(4-Amino-2-(methylmercapto)pyrimidin-5-yl)acrylate
EINECS	Contact for details

Quality Control

Our (E)-Ethyl 3-(4-Amino-2-(Methylthio)Pyrimidin-5-Yl)Acrylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed batch-specific results are provided to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.