Description

L-Norleucine, 2-(Hydroxymethyl)- (9Ci) is a non-proteinogenic amino acid derivative characterized by a hydroxymethyl side chain modification. This structural feature makes it a valuable chiral building block and intermediate for advanced organic synthesis, particularly in pharmaceutical research and development. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for creating novel peptide mimetics, active pharmaceutical ingredients (APIs), and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and synthesis of novel therapeutic peptides, peptidomimetics, and small molecule drugs.
• Biochemical Research: Used as a specialized substrate or inhibitor in enzymatic studies and metabolic pathway investigations.
• Peptide Chemistry: Serves as a modified amino acid residue for introducing structural diversity and specific functional groups into synthetic peptides.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying protein-protein interactions and cellular processes.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in stereoselective synthesis routes for complex organic molecules.

Basic Information

Product Name	L-Norleucine, 2-(Hydroxymethyl)- (9Ci)
CAS No.	211188-23-7
Molecular Formula	C7H15NO3
Molecular Weight	161.20 g/mol
Synonyms	(2S)-2-Amino-2-(hydroxymethyl)hexanoic acid; L-2-(Hydroxymethyl)norleucine; (S)-2-Amino-2-(hydroxymethyl)caproic acid; 2-(Hydroxymethyl)-L-norleucine; H-L-Hmn-OH; L-α-Amino-α-(hydroxymethyl)caproic acid
EINECS	Contact for details

Quality Control

Our L-Norleucine, 2-(Hydroxymethyl)- (9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and specific test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.