Description

Fmoc-D-His(Boc)-Oh Cha CAS NO 210755-31-0 is a high-purity, orthogonally protected derivative of the D-isomer of the amino acid histidine, specifically designed for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise stereochemical control and side-chain protection during the assembly of complex peptides and peptidomimetics. It is an essential building block for the pharmaceutical, biotechnology, and life sciences industries, enabling the development of novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated, stepwise construction of peptide chains.
• Pharmaceutical Research & Development: For the synthesis of peptide-based drug candidates, including hormone analogs, enzyme inhibitors, and receptor agonists/antagonists.
• Bioconjugation & Probe Development: Utilized to incorporate a uniquely functionalizable histidine residue into peptides for labeling, imaging, or creating affinity tags.
• Combinatorial Chemistry Libraries: Serves as a variable building block in the generation of diverse peptide libraries for high-throughput screening.
• Academic & Institutional Research: Fundamental research in biochemistry, structural biology, and medicinal chemistry exploring protein-protein interactions and peptide function.
• GMP Manufacturing: Suitable for use in the production of active pharmaceutical ingredients (APIs) for clinical trial materials under controlled conditions.

Basic Information

Product Name	Fmoc-D-His(Boc)-Oh Cha
CAS No.	210755-31-0
Molecular Formula	C₂₆H₂₉N₃O₆
Molecular Weight	479.53 g/mol
Synonyms	Fmoc-D-histidine(Boc)-OH; N-α-Fmoc-N-π-Boc-D-histidine; (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[1-(tert-butoxycarbonyl)-1H-imidazol-4-yl]propanoic acid; Fmoc-His(Boc)-D-OH; Fmoc-D-His(Boc)-OH; Boc-D-His(Fmoc)-OH; D-Histidine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N(pi)-(1,1-dimethylethoxy)carbonyl]-; N-α-Fmoc-N-im-Boc-D-histidine
EINECS	Contact for details

Quality Control

Every batch of Fmoc-D-His(Boc)-Oh Cha is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive peptide synthesis applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as chiral purity, chemical purity (by HPLC), and residual solvent content. Our quality commitment aligns with the standards expected for research and cGMP-grade intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.