Description

Boc-D-His(Tos)-Oh Dcha is a protected derivative of the non-natural D-histidine amino acid, featuring tert-butyloxycarbonyl (Boc) and tosyl (Tos) protecting groups, supplied as a dicyclohexylamine (DCHA) salt. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering enhanced stability and controlled reactivity during solid-phase and solution-phase peptide coupling. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced peptide chemistry, medicinal chemistry, and the development of novel therapeutic agents.

Application

• Peptide Synthesis: A key chiral intermediate for the controlled incorporation of D-histidine into custom peptide sequences.
• Pharmaceutical Research: Used in the R&D of peptide-based drugs, hormone analogs, and diagnostic agents.
• Medicinal Chemistry: Serves as a building block for creating libraries of peptidomimetics and bioactive compounds for screening.
• Bioconjugation: Can be utilized in the preparation of labeled peptides or peptide-protein conjugates for biochemical studies.
• Academic Research: Employed in university and institutional labs for studying peptide structure-activity relationships and enzyme-substrate interactions.

Basic Information

Product Name	Boc-D-His(Tos)-Oh Dcha
CAS No.	210694-29-4
Molecular Formula	C26H40N4O6S
Molecular Weight	536.69 g/mol
Synonyms	Boc-D-histidine(Tos)-OH dicyclohexylamine salt; N-α-(tert-Butoxycarbonyl)-N-π-tosyl-D-histidine DCHA salt; (2R)-2-[(tert-Butoxycarbonyl)amino]-3-[1-(4-methylphenyl)sulfonyl-1H-imidazol-4-yl]propanoic acid dicyclohexylamine salt; Boc-D-His(Tos)-OH·DCHA; Boc-D-His(Tosyl)-OH DCHA salt; BOC-D-HISTIDINE(TOS)-OH DCHA SALT; D-Histidine, N-[(1,1-dimethylethoxy)carbonyl]-N-[(4-methylphenyl)sulfonyl]-, compd. with dicyclohexylamine (1:1)
EINECS	Contact for details

Quality Control

Our Boc-D-His(Tos)-Oh Dcha is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. We provide full traceability and a Certificate of Analysis (COA) with each shipment, detailing key specifications such as assay, enantiomeric excess, and residual solvent levels to ensure compliance with research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.