Description

Fmoc-Cys((Rs)-2,3-Di(Palmitoyloxy)-Propyl)-Oh is a specialized, lipidated cysteine derivative designed for advanced peptide synthesis. This compound is critical for introducing a palmitoyl-modified cysteine residue, enabling the creation of peptides with enhanced membrane affinity and stability. It is an essential building block for researchers and manufacturers in pharmaceutical development, bioconjugation, and the synthesis of therapeutic peptides and vaccines, particularly those targeting lipid-based delivery systems.

Application

• Lipopeptide Synthesis: Key building block for incorporating lipidated cysteine residues into peptide chains to modulate hydrophobicity and cellular uptake.
• Vaccine Adjuvant Development: Used in the research and production of peptide-based vaccine candidates that require toll-like receptor (TLR) targeting or enhanced immunogenicity.
• Therapeutic Peptide Production: Enables the creation of peptide drugs with improved pharmacokinetic profiles through lipidation strategies.
• Cell-Penetrating Peptides (CPPs): Facilitates the synthesis of CPPs designed for more efficient intracellular delivery of cargo molecules.
• Bioconjugation and Protein Labeling: Serves as a versatile handle for site-specific lipidation of proteins and other biomolecules.
• Chemical Biology Research: A valuable tool for studying protein lipidation, membrane protein interactions, and signal transduction pathways.

Basic Information

Product Name	Fmoc-Cys((Rs)-2,3-Di(Palmitoyloxy)-Propyl)-Oh
CAS No.	210532-98-2
Molecular Formula	C58H91NO8S
Molecular Weight	962.4 g/mol
Synonyms	Fmoc-S-(2,3-bis(palmitoyloxy)propyl)-L-cysteine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-[2,3-bis(hexadecanoyloxy)propyl]-L-cysteine; Fmoc-Cys(Pam2)-OH; Fmoc-Cys(di-Pal)-OH; Fmoc-Cysteine(Pam2)-OH; Fmoc-L-Cys(S-(2,3-bis(palmitoyloxy)propyl))-OH; TLR2 Ligand Precursor; Lipopeptide Building Block Cysteine Derivative
EINECS	Contact for details

Quality Control

Our Fmoc-Cys((Rs)-2,3-Di(Palmitoyloxy)-Propyl)-Oh is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent internal quality standards to support our clients' needs in GMP-compatible synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.