Description

Fmoc-D-Met-Opfp CAS NO 210473-10-2 is a protected amino acid derivative, specifically the pentafluorophenyl (OPfp) ester of Fmoc-D-methionine, designed for efficient peptide synthesis. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of D-methionine with high coupling efficiency and minimal racemization. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, peptide-based drugs, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key activated ester for the rapid and efficient coupling of D-methionine residues in automated and manual peptide assembly.
• Pharmaceutical Intermediate: For the research and production of novel therapeutic peptides, including antimicrobial peptides (AMPs) and hormone analogs.
• Bioconjugation and Labeling: Utilized in the site-specific modification of peptides and proteins for diagnostic or drug delivery applications.
• Combinatorial Chemistry: Serves as a valuable building block in libraries for drug discovery and high-throughput screening.
• Academic and R&D Laboratories: For fundamental research in peptide chemistry, structure-activity relationship (SAR) studies, and methodology development.
• Synthesis of Non-Natural Peptides: Enables the creation of peptides with enhanced stability, bioavailability, or specific biological activity.

Basic Information

Product Name	Fmoc-D-Met-Opfp
CAS No.	210473-10-2
Molecular Formula	C₂₆H₂₀F₅NO₅S
Molecular Weight	553.50 g/mol
Synonyms	Fmoc-D-methionine pentafluorophenyl ester; N-(9-Fluorenylmethoxycarbonyl)-D-methionine pentafluorophenyl ester; Fmoc-D-Met-OPfp; (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-methylsulfanyl-butanoic acid 2,3,4,5,6-pentafluorophenyl ester; Fmoc-D-Met-OPh(2,3,4,5,6-F5); N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-methionine 2,3,4,5,6-pentafluorophenyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-D-Met-Opfp is manufactured under strict quality-controlled conditions to ensure high chemical purity and optimal performance in sensitive peptide synthesis. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.