Description

(R)-2-Aminomethyl-4-Methyl-Pentanoic Acid CAS NO 210345-89-4 is a high-purity, non-proteinogenic amino acid derivative characterized by its chiral (R)-configuration. This compound is a critical chiral building block for the synthesis of complex pharmaceuticals and bioactive molecules, offering precise stereochemical control. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries for applications in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in peptidomimetics and enzyme inhibitors.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce specific structural and functional motifs.
• Drug Discovery & Medicinal Chemistry: Serves as a constrained amino acid analog in structure-activity relationship (SAR) studies and lead optimization.
• Bioconjugation & Probe Development: The amine and carboxylic acid functional groups allow for site-specific labeling and conjugation in biochemical tools.
• Catalyst & Ligand Synthesis: A precursor for chiral ligands used in asymmetric catalysis.
• Academic & Industrial Research: A valuable reference standard and building block for chemical biology and organic synthesis research.

Basic Information

Product Name	(R)-2-Aminomethyl-4-Methyl-Pentanoic Acid
CAS No.	210345-89-4
Molecular Formula	C8H17NO2
Molecular Weight	159.23 g/mol
Synonyms	(R)-2-(Aminomethyl)-4-methylpentanoic acid; (R)-2-Aminomethyl-4-methylvaleric acid; (R)-HomoLeu(2-NH2); D-2-Aminomethyl-4-methylpentanoic acid; (2R)-2-(Aminomethyl)-4-methylpentanoic acid; (R)-α-Amino-γ-methylnorvaline; (R)-2-(Aminomethyl)-4-methylvaleric Acid
EINECS	Contact for details

Quality Control

Our (R)-2-Aminomethyl-4-Methyl-Pentanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-purity standards for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.