Description

n-Acetyl-L-Tryptophyl-L-α-Glutamyl-L-Histidyl-n-[2-Oxo-4-(Trifluoromethyl)-2H-1-Benzopyran-7-Yl]-L-α-Asparagine CAS NO 210344-99-3 is a complex, high-purity synthetic peptide derivative designed for advanced research and development applications. This compound is valued for its specific molecular architecture, which incorporates a benzopyran moiety, making it a critical intermediate or reference standard in the development of novel bioactive molecules. It is primarily sought after by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on peptide-based therapeutics, enzyme inhibitors, and molecular probes. The product is supplied under stringent quality control to ensure batch-to-batch consistency and reliability for sensitive experimental work.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or a reference standard in the synthesis and screening of novel peptide-based drug candidates, particularly those targeting specific enzymatic pathways.
• Biochemical Probe Development: Used in the design and study of molecular probes for investigating protein-protein interactions, receptor binding, and signal transduction mechanisms due to its unique structural features.
• Enzyme Inhibitor Studies: Acts as a potential scaffold or precursor for developing selective enzyme inhibitors, leveraging the tryptophan, histidine, and benzopyran components for targeted activity.
• Academic & Contract Research: Employed in university and CRO (Contract Research Organization) settings for fundamental research in medicinal chemistry, peptide science, and chemical biology.
• Process Development & Scale-up: Used as a benchmark compound during the optimization and validation of synthetic routes for complex peptide molecules in process chemistry.
• Analytical Standard: Functions as a high-purity standard for analytical method development and validation in HPLC, LC-MS, and other chromatographic techniques within quality control laboratories.

Basic Information

Item	Details
Product Name	n-Acetyl-L-Tryptophyl-L-α-Glutamyl-L-Histidyl-n-[2-Oxo-4-(Trifluoromethyl)-2H-1-Benzopyran-7-Yl]-L-α-Asparagine
CAS No.	210344-99-3
Molecular Formula	C43H44F3N7O12
Molecular Weight	907.85 g/mol
Synonyms	Ac-Try-Glu-His-(Coumarin-Asp); Ac-Try-Glu-His-(7-Asp-4-trifluoromethylcoumarin); Ac-Try-Glu-His-Asp-AFC; Ac-Tryptophyl-Glutamyl-Histidyl-(7-Aspartyl-4-trifluoromethylcoumarin); Fluorogenic Peptide Substrate Analog; Caspase Substrate Derivative; 7-Asp-4-trifluoromethylcoumarin labeled peptide; Ac-WEHD-AFC related compound
EINECS	Contact for details

Quality Control

Our n-Acetyl-L-Tryptophyl-L-α-Glutamyl-L-Histidyl-n-[2-Oxo-4-(Trifluoromethyl)-2H-1-Benzopyran-7-Yl]-L-α-Asparagine is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets the high standards required for research applications. Each batch is characterized using advanced techniques including HPLC, MS, and NMR for identity and purity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and other critical parameters is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.