Description

Fmoc-Phe(3-I)-Oh is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for the controlled introduction of iodinated phenylalanine residues into peptide chains, enabling advanced research and development. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic laboratories focused on peptide-based drug discovery, chemical biology, and the development of novel therapeutic agents and diagnostic tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the automated, sequential assembly of custom peptides.
• Pharmaceutical Research: Synthesis of peptide drug candidates, hormone analogs, and targeted therapeutics.
• Chemical Biology & Bioconjugation: Enables site-specific labeling, cross-linking, or functionalization of peptides via the iodine moiety.
• Proteomics & Biochemistry: Used in the study of protein-protein interactions and structure-activity relationships (SAR).
• Radiopharmaceutical Precursor: The iodine atom provides a potential site for radioiodination in diagnostic imaging agent development.
• Material Science: Incorporation into bio-inspired polymers and advanced biomaterials.

Basic Information

Product Name	Fmoc-Phe(3-I)-Oh
CAS No.	210282-32-9
Molecular Formula	C24H20INO4
Molecular Weight	521.32 g/mol
Synonyms	Fmoc-3-iodo-L-phenylalanine; N-(9-Fluorenylmethoxycarbonyl)-3-iodo-L-phenylalanine; Fmoc-L-Phe(3-I)-OH; (2S)-3-(3-iodophenyl)-2-[(9H-fluoren-9-ylmethoxy)formamido]propanoic acid; Fmoc-3-I-Phe-OH; N-α-Fmoc-3-iodo-L-phenylalanine; Fmoc-Phe(3-I)-OH; Fmoc-3-Iodo-Phe-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Phe(3-I)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -20.0° (c=1, DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.