Description

2-Hydroxy-5-(Trifluoromethyl)Benzaldehyde is a versatile fluorinated aromatic aldehyde that serves as a critical building block in advanced organic synthesis. Its unique structure, combining a phenolic hydroxyl group with a trifluoromethyl substituent, enables precise molecular design for high-value applications. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries seeking to incorporate fluorine atoms for enhanced bioactivity and metabolic stability.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for anti-inflammatory and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Building block for developing next-generation herbicides, fungicides, and insecticides where the trifluoromethyl group improves lipophilicity and environmental persistence.
• Ligand and Catalyst Development: Used to create sophisticated chelating ligands for transition metal catalysts in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Monomer or functionalization agent for designing specialty polymers, liquid crystals, and organic electronic materials with tailored properties.
• Fluorescent Probe Synthesis: Serves as a starting material for synthesizing fluorophores and molecular sensors used in bioimaging and diagnostic assays.

Basic Information

Product Name	2-Hydroxy-5-(Trifluoromethyl)Benzaldehyde
CAS No.	210039-65-9
Molecular Formula	C8H5F3O2
Molecular Weight	190.12 g/mol
Synonyms	5-(Trifluoromethyl)salicylaldehyde; 2-Hydroxy-5-(trifluoromethyl)benzaldehyde; Salicylaldehyde, 5-(trifluoromethyl)-; 5-Trifluoromethylsalicylaldehyde; 2-Formyl-4-(trifluoromethyl)phenol; α-Hydroxy-5-(trifluoromethyl)benzaldehyde; 5-Trifluoromethoxysalicylaldehyde (common misnomer)
EINECS	Contact for details

Quality Control

Every batch of 2-Hydroxy-5-(Trifluoromethyl)Benzaldehyde is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure traceability and consistency for your critical R&D and scale-up processes. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profiles via HPLC, GC, NMR, and IR is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, reducing agents, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.