Description

n-Boc-4-Bromo-2-Fluoroaniline is a high-purity, protected aniline derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile, reactive scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working in pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for drug discovery and scale-up.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated and brominated aromatic systems.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the fluorine and bromine substituents modulate biological activity and stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of monomers and functionalized polymers for advanced materials with specific electronic or optical properties.
• Peptidomimetics and Bio-conjugates: The Boc-protected amine is instrumental in peptide chemistry and for creating targeted bio-conjugates in drug delivery systems.
• Chemical Biology Probes: Utilized to synthesize fluorescent tags, affinity labels, and other molecular probes for biological target identification and validation.

Basic Information

Product Name	n-Boc-4-Bromo-2-Fluoroaniline
CAS No.	209958-42-9
Molecular Formula	C11H13BrFNO2
Molecular Weight	290.13 g/mol
Synonyms	tert-Butyl (4-bromo-2-fluorophenyl)carbamate; 1-(tert-Butoxycarbonylamino)-4-bromo-2-fluorobenzene; 4-Bromo-2-fluoroaniline N-Boc derivative; N-Boc-4-bromo-2-fluoroaniline; N-(tert-Butoxycarbonyl)-4-bromo-2-fluoroaniline; Boc-4-Br-2-F-aniline; (4-Bromo-2-fluorophenyl)carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our n-Boc-4-Bromo-2-Fluoroaniline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.