Description

4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-1,5-dihydro- is a high-purity nucleoside analog derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical pharmacologically active intermediate for the synthesis of novel antiviral and anticancer agents. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and contract research organizations (CROs) engaged in the discovery of next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nucleoside analog drugs targeting viral infections and oncology.
• Antiviral Drug Research: Used in the development of potential therapeutics against a range of DNA and RNA viruses.
• Oncology Research: Investigated as a precursor for antimetabolite chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism and polymerase function.
• Preclinical Development: Sourced for formulation studies, pharmacokinetic profiling, and toxicology assessments during early drug development stages.
• Process Chemistry: Used for scaling up synthetic routes and optimizing manufacturing processes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-1,5-dihydro-
CAS No.	209799-75-7
Molecular Formula	C12H15N5O5
Molecular Weight	309.28 g/mol
Synonyms	2-Amino-7-((2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl)-4H-pyrrolo[3,2-d]pyrimidin-4-one; 2-Amino-7-((2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl)-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one; 2-Amino-7-(3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl)-4H-pyrrolo[3,2-d]pyrimidin-4-one (stereoisomer); Nucleoside Pyrrolopyrimidine Derivative; 209799-75-7
EINECS	Contact for details

Quality Control

Our pharmaceutical-grade material is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the stringent requirements for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.