Description

Diprotin A Tfa (Synonyms: Ile-Pro-Ile (Tfa)) is a modified tripeptide inhibitor of dipeptidyl peptidase IV (DPP-IV). This compound is a critical research tool for studying enzymatic pathways related to glucose metabolism and immune regulation. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in metabolic disease research and drug discovery programs.

Application

• Biochemical Research: A potent and selective inhibitor for DPP-IV enzyme activity studies in vitro.
• Drug Discovery: Used as a reference standard and lead compound in the development of novel therapeutics for Type 2 diabetes.
• Metabolic Pathway Analysis: Essential for investigating the role of DPP-IV in incretin hormone degradation and glucose homeostasis.
• Enzyme Kinetics: Serves as a substrate analog to study inhibition mechanisms and calculate kinetic parameters (Ki, IC50).
• Cell-Based Assays: Used in cellular models to probe DPP-IV function in immunology and endocrinology.
• Peptide Chemistry Reference: Acts as a building block or model compound in peptide synthesis and modification research.

Basic Information

Product Name	Diprotin A Tfa
CAS No.	209248-71-5
Molecular Formula	C₂₀H₃₂N₄O₆•C₂HF₃O₂
Molecular Weight	570.55 g/mol
Synonyms	Ile-Pro-Ile trifluoroacetate salt; Isoleucyl-prolyl-isoleucine TFA; Diprotin A trifluoroacetate; N-Ile-Pro-Ile TFA; DPP-IV Inhibitor I; H-Ile-Pro-Ile-OH TFA; (2S)-1-[(2S)-2-[[(2S)-2-Amino-4-methylpentanoyl]amino]-1-pyrrolidinyl]-4-methyl-1-oxopentan-2-aminium 2,2,2-trifluoroacetate
EINECS	Contact for details

Quality Control

Our Diprotin A Tfa is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture content. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to ensure traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.