Description

7-Benzenesulfonyl-4-Chloro-5-Iodo-7H-Pyrrolo[2,3-D]Pyrimidine is a high-purity, multi-functionalized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because its unique halogenated and sulfonylated pyrrolopyrimidine core serves as a versatile scaffold for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as medicinal chemistry, library synthesis, and the development of kinase inhibitors or other biologically active compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the development of small molecule libraries for high-throughput screening.
• Kinase Inhibitor Development: The pyrrolo[2,3-d]pyrimidine scaffold is a privileged structure in the design of ATP-competitive kinase inhibitors for oncology and inflammatory diseases.
• Agrochemical Synthesis: Serves as an intermediate in the research and development of new active ingredients for crop protection.
• Chemical Biology Probes: Utilized in the creation of molecular probes to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	7-Benzenesulfonyl-4-Chloro-5-Iodo-7H-Pyrrolo[2,3-D]Pyrimidine
CAS No.	208459-84-1
Molecular Formula	C12H7ClIN3O2S
Molecular Weight	419.62 g/mol
Synonyms	4-Chloro-5-iodo-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine; 7-(Benzenesulfonyl)-4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine; 4-Chloro-5-iodo-7-(phenylsulfonyl)pyrrolo[2,3-d]pyrimidine; 208459-84-1; 7H-Pyrrolo[2,3-d]pyrimidine, 4-chloro-5-iodo-7-(phenylsulfonyl)-; 4-Chloro-5-iodo-7-(benzenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine
EINECS	Contact for details

Quality Control

Our 7-Benzenesulfonyl-4-Chloro-5-Iodo-7H-Pyrrolo[2,3-D]Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and development applications. Certificates of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation (by NMR, IR, and/or MS), and impurity profiles are provided with every shipment. We support development from milligram to kilogram scale with consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.