Description

Sodium Taurodeoxycholate Hydrate is a high-purity conjugated bile salt derivative, essential for its role as a potent biological detergent and membrane-disrupting agent. Its primary value lies in its ability to solubilize lipids and membrane proteins while maintaining physiological compatibility, making it a critical reagent in life science research and pharmaceutical development. This product is indispensable for researchers and manufacturers in the biotechnology, pharmaceutical, and diagnostic sectors, particularly for applications involving cell lysis, protein isolation, and in vitro modeling of biological systems.

Application

• Biochemical Research & Cell Biology: Used as a mild, effective detergent for the isolation and solubilization of membrane proteins and lipids from cellular and organelle membranes.
• Pharmaceutical Formulation: Serves as a critical excipient in drug delivery systems, particularly for enhancing the solubility and bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs).
• In Vitro Diagnostics (IVD): Employed in reagent formulations for clinical diagnostic kits, where it acts to lyse cells and release intracellular components for analysis.
• Virology & Vaccine Development: Utilized in the purification and study of enveloped viruses, as it can disrupt viral membranes without denaturing protein antigens.
• Lipid & Bile Acid Metabolism Studies: Functions as a standard or reference compound in analytical methods (HPLC, MS) to study bile acid pathways and related metabolic disorders.
• Biophysical Studies: Applied in the formation of micelles and mixed micelles to study membrane dynamics, protein-lipid interactions, and for crystallizing membrane proteins.

Basic Information

Product Name	Sodium Taurodeoxycholate Hydrate
CAS No.	207737-97-1
Molecular Formula	C26H44NNaO7S · xH2O
Molecular Weight	Anhydrous: 537.68 g/mol
Synonyms	Taurodeoxycholic Acid Sodium Salt Hydrate; Sodium Taurodeoxycholate; TDCA-Na; 3α,12α-Dihydroxy-5β-cholan-24-oic Acid N-(2-Sulfoethyl)amide Sodium Salt; N-(3α,12α-Dihydroxy-5β-cholan-24-oyl)-taurine Sodium Salt; Deoxycholyltaurine Sodium Salt; Tauroursodeoxycholate Sodium (Note: This is a common misnomer, chemically distinct); Sodium Taurodeoxycholic Acid
EINECS	Contact for details

Quality Control

Our Sodium Taurodeoxycholate Hydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) detailing purity, water content, and specific impurity profiles are available upon request. We can supply material compliant with various internal specifications for research use (RUO) and can discuss requirements for higher-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture, which can affect purity and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0% w/w
Purity (HPLC, Total Bile Acids)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%
Solubility	Freely soluble in water, methanol; soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.