Description

Fmoc-Glu-2-Phenylisopropyl Ester CAS NO 207305-97-3 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). Its core value lies in providing a reactive glutamic acid side chain that is orthogonally protected, enabling precise and efficient construction of complex peptides. This compound is critically needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for introducing glutamic acid residues with a protected carboxylic acid side chain, facilitating the synthesis of complex peptide sequences.
• Pharmaceutical Research & Development: For the discovery and production of peptide-based drug candidates, including hormones, enzyme inhibitors, and targeted therapeutics.
• Combinatorial Chemistry Libraries: Used in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Bioconjugation and Probe Synthesis: Enables the site-specific attachment of labels, tags, or other molecules to peptides for diagnostic and imaging applications.
• Academic & Institutional Research: A fundamental reagent in biochemistry and molecular biology laboratories for studying protein structure, function, and interactions.
• Custom Peptide Service Providers: A staple raw material for CROs and CDMOs offering bespoke peptide synthesis services to the biotech and pharmaceutical industries.

Basic Information

Product Name	Fmoc-Glu-2-Phenylisopropyl Ester
CAS No.	207305-97-3
Molecular Formula	C₂₉H₂₉NO₆
Molecular Weight	487.55 g/mol
Synonyms	Fmoc-Glu(O-2-PhiPr)-OH; N-(9-Fluorenylmethoxycarbonyl)-L-glutamic acid 2-phenylisopropyl ester; Fmoc-L-glutamic acid 2-phenyl-1-methylethyl ester; Fmoc-Glu(OtBu)-OH analog (protected form); Fmoc-Glu(O-2-Phenylisopropyl)-OH; Protected Fmoc-glutamate ester; Peptide synthesis building block for Glu; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]pentanedioic acid 5-(2-phenylpropan-2-yl) ester
EINECS	Contact for details

Quality Control

Our Fmoc-Glu-2-Phenylisopropyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, to ensure it meets the high standards required for sensitive peptide synthesis applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability, consistency, and reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. For long-term storage, consider desiccants or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.