Description

Fmoc-α-Methyl-L-Ser CAS NO 207117-28-0 is a high-purity, non-proteinogenic amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for introducing sterically hindered, methyl-substituted serine analogs into peptide chains, enabling the creation of novel structures with enhanced metabolic stability and unique conformational properties. It is an essential building block for pharmaceutical researchers, medicinal chemists, and biotech companies developing next-generation peptide therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, facilitating the incorporation of α-methyl-serine residues.
• Medicinal Chemistry & Drug Discovery: Used to synthesize peptide analogs and mimetics with improved bioavailability, protease resistance, and target specificity for therapeutic candidates.
• Peptidomimetic Design: Essential for constructing constrained peptides and foldamers where the α-methyl group restricts backbone conformation and modulates biological activity.
• Biochemical Research: Serves as a tool for studying enzyme-substrate interactions, protein folding, and structure-activity relationships (SAR) in model peptide systems.
• API Intermediate Production: Acts as a sophisticated intermediate in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) for clinical development.

Basic Information

Product Name	Fmoc-α-Methyl-L-Ser
CAS No.	207117-28-0
Molecular Formula	C20H21NO5
Molecular Weight	355.39 g/mol
Synonyms	Fmoc-α-Me-L-Ser-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-α-methyl-L-serine; Fmoc-α-Methylserine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-2-methyl-3-hydroxypropanoic acid; Fmoc-Amd(Me)-OH; Fmoc-L-α-Methylserine; N-Fmoc-α-methyl-L-serine; Fmoc-α-Me-Ser-OH
EINECS	Contact for details

Quality Control

Our Fmoc-α-Methyl-L-Ser is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity, typically exceeding 98.0% (HPLC). Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to cGMP principles for pharmaceutical intermediates, and our quality protocols are designed to meet the stringent requirements of research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.