Description

3,4-Difluoro-2-(Difluoromethoxy)Aniline is a high-purity, multi-fluorinated aniline derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine substituents and a difluoromethoxy group, makes it an essential intermediate for introducing specific physicochemical properties into target molecules. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries to create novel active ingredients with enhanced metabolic stability, lipophilicity, and bioavailability.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms improve compound stability and activity.
• Liquid Crystal Materials: Serves as a building block for fluorinated components in liquid crystal displays (LCDs) to optimize dielectric anisotropy and viscosity.
• Functional Material Research: Intermediate for creating specialty polymers, dyes, and organic electronic materials that require specific fluorine-based properties.
• Chemical Research & Development: A versatile reagent for exploring new fluorination methodologies and constructing complex heterocyclic compounds in academic and industrial labs.

Basic Information

Product Name	3,4-Difluoro-2-(Difluoromethoxy)Aniline
CAS No.	206546-19-2
Molecular Formula	C7H5F4NO
Molecular Weight	195.12 g/mol
Synonyms	2-(Difluoromethoxy)-3,4-difluoroaniline; 3,4-Difluoro-2-(difluoromethoxy)benzenamine; 2-Amino-4,5-difluoro-1-(difluoromethoxy)benzene; Benzenamine, 3,4-difluoro-2-(difluoromethoxy)-; 206546-19-2; 3,4-DF-2-DFMA; DFDFA
EINECS	Contact for details

Quality Control

Our 3,4-Difluoro-2-(Difluoromethoxy)Aniline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the stringent requirements of our global customer base. Certificates of Analysis (COA) documenting all critical quality attributes are provided with each shipment. We support compliance with relevant regulatory frameworks, including REACH and ICH Q7 guidelines for active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber packaging, or stored in darkness.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.