Description

Fmoc-L-Norarginine(Boc)2-Oh, (S)-n-α-(9-Fluorenylmethyloxycarbonyl)-N,n-Bis-T-Butyloxycarbonyl-2-Amino-4-Guanidino-Butyric Acid CAS NO 206183-06-4 is a high-purity, orthogonally protected arginine derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over the guanidino group during complex peptide assembly, enabling the synthesis of peptides with enhanced solubility and biological activity. It is an essential building block for pharmaceutical R&D, particularly in the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, facilitating the controlled incorporation of arginine analogs into peptide chains.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates targeting cardiovascular diseases, metabolic disorders, and infectious diseases.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides or affinity probes for biochemical assays and diagnostic imaging.
• Enzyme Substrate & Inhibitor Synthesis: Essential for manufacturing substrates or inhibitors for proteases like trypsin and thrombin, which are pivotal in biochemical research.
• Antimicrobial Peptide (AMP) Production: Used to synthesize arginine-rich antimicrobial peptides, which are a promising class of novel antibiotics.
• Cell-Penetrating Peptide (CPP) Fabrication: A critical component in the production of CPPs designed for intracellular delivery of therapeutic cargo.

Basic Information

Product Name	Fmoc-L-Norarginine(Boc)2-Oh
CAS No.	206183-06-4
Molecular Formula	C32H42N4O8
Molecular Weight	610.70 g/mol
Synonyms	(S)-n-α-(9-Fluorenylmethyloxycarbonyl)-N,n-Bis-T-Butyloxycarbonyl-2-Amino-4-Guanidino-Butyric Acid; Fmoc-Norarginine(Boc)2-OH; Fmoc-L-2-Amino-4-[(tert-butoxycarbonyl)amino]-4-[(tert-butoxycarbonyl)imino]butanoic Acid; Fmoc-NorArg(Boc)2-OH; Nα-Fmoc-Nω,Nω'-bis-Boc-nor-L-arginine; Fmoc-Nor-L-Arg(Boc)2-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-((((tert-butoxycarbonyl)amino)((tert-butoxycarbonyl)imino)methyl)amino)butanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-L-Norarginine(Boc)2-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We support compliance with cGMP and ICH guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake. For long-term storage under inert atmosphere, contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.