Description

(S)-Fmoc-(4-Pmc-Gyanidino)-Phenylalanine is a protected, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is critical for the solid-phase synthesis of complex peptides, particularly those requiring the incorporation of a protected guanidino group. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy, enabling the controlled assembly of peptide chains.
• Pharmaceutical Research: Used in the development of peptide drugs targeting various diseases, where the guanidino group is crucial for bioactivity.
• Bioconjugation: Serves as a specialized linker or modifier for creating peptide-protein or peptide-small molecule conjugates.
• Chemical Biology Probes: Incorporation into peptides used as tools to study enzyme function, protein-protein interactions, and cellular pathways.
• Antibiotic Mimetics: A building block for synthesizing peptides that mimic natural antimicrobial peptides (AMPs).
• High-Purity Reference Standard: Used as a certified reference material for analytical method development and quality control in peptide production.

Basic Information

Product Name	(S)-Fmoc-(4-Pmc-Gyanidino)-Phenylalanine
CAS No.	206060-56-2
Molecular Formula	C₃₆H₄₃N₅O₆S
Molecular Weight	673.83 g/mol
Synonyms	Fmoc-Phe(4-Pmc-Guan)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[[(2,2,5,7,8-pentamethylchroman-6-yl)sulfonyl]guanidino]-L-phenylalanine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-((((2,2,5,7,8-pentamethylchroman-6-yl)sulfonyl)guanidino)phenyl)propanoic acid; Fmoc-L-Phe(4-Pmc-Guan)-OH; Fmoc-Phenylalanine(Pmc-Guanidine)-OH; Fmoc-4-Guanidino(Pmc)-L-Phenylalanine; Fmoc-4-(Pmc-guanidino)-L-Phe-OH
EINECS	Contact for details

Quality Control

Every batch of (S)-Fmoc-(4-Pmc-Gyanidino)-Phenylalanine is manufactured and tested under strict quality management systems. We ensure high purity and consistency through advanced analytical techniques including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your research and cGMP-compliant manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.