Description

Fmoc-L-Pentafluorophenylalanine CAS NO 205526-32-5 is a specialized, non-natural amino acid derivative where the phenyl ring of phenylalanine is fully substituted with fluorine atoms and protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is a critical building block in modern solid-phase peptide synthesis (SPPS), enabling the precise incorporation of a highly fluorinated aromatic side chain into peptide sequences. It is primarily utilized by research institutions, pharmaceutical developers, and biotechnology companies engaged in creating novel peptides with enhanced metabolic stability, altered binding affinity, or unique physicochemical properties for therapeutic and diagnostic applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated, stepwise construction of custom peptide chains.
• Pharmaceutical Research & Development: Used to synthesize peptide-based drug candidates where fluorination improves bioavailability, target selectivity, and resistance to enzymatic degradation.
• Chemical Biology & Proteomics: Incorporation into peptide probes and substrates to study protein-protein interactions, enzyme mechanisms, and cellular signaling pathways.
• Material Science: Serves as a monomer for creating fluorinated peptidomimetics and bio-inspired polymers with unique surface properties and stability.
• Agrochemical Research: Potential use in developing novel bioactive peptides for crop protection agents.
• Diagnostic Agent Development: Useful in synthesizing peptide tracers and contrast agents for imaging technologies like PET and MRI.

Basic Information

Product Name	Fmoc-L-Pentafluorophenylalanine
CAS No.	205526-32-5
Molecular Formula	C24H16F5NO4
Molecular Weight	477.38 g/mol
Synonyms	Fmoc-Phe(2,3,4,5,6-F5)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(pentafluorophenyl)-L-alanine; Fmoc-L-Phe(F5)-OH; Nα-Fmoc-L-pentafluorophenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(pentafluorophenyl)propanoic acid; Fmoc-4F-Phe-OH; Fmoc-Pentafluorophenylalanine; Fmoc-3-(Pentafluorophenyl)-L-alanine
EINECS	Contact for details

Quality Control

Our Fmoc-L-Pentafluorophenylalanine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.