Description

Fmoc-L-3,4,5-Trifluorophenylalanine is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is essential for introducing the unique physicochemical properties of a trifluoromethylated aromatic side chain into peptide backbones, enhancing metabolic stability and lipophilicity. It is a critical building block for researchers and manufacturers in pharmaceutical development, agrochemical discovery, and materials science who require precise structural control and reliable quality.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the controlled assembly of complex peptides.
• Pharmaceutical Research: Used in the development of peptide-based therapeutics, enzyme inhibitors, and diagnostic agents where fluorination improves bioavailability and binding affinity.
• Chemical Biology & Proteomics: Serves as a tool for site-specific incorporation of fluorinated motifs to study protein structure, function, and interactions.
• Agrochemical Discovery: Incorporated into novel active ingredients to enhance stability, permeability, and environmental persistence.
• Materials Science: A precursor for synthesizing specialized polymers and advanced materials with tailored surface properties and stability.

Basic Information

Product Name	Fmoc-L-3,4,5-Trifluorophenylalanine
CAS No.	205526-30-3
Molecular Formula	C24H18F3NO4
Molecular Weight	441.40 g/mol
Synonyms	Fmoc-3,4,5-trifluoro-L-phenylalanine; N-(9-Fluorenylmethoxycarbonyl)-3,4,5-trifluoro-L-phenylalanine; Fmoc-Tff-OH; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(3,4,5-trifluorophenyl)propanoic acid; N-α-Fmoc-3,4,5-trifluoro-L-phenylalanine; Fmoc-L-Phe(3,4,5-F3)-OH; Fmoc-3,4,5-F3-Phe-OH
EINECS	Contact for details

Quality Control

Our Fmoc-L-3,4,5-Trifluorophenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with exacting research and production standards. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.