Description

Fmoc-3-Chloro-D-Phenylalanine is a protected, non-natural amino acid derivative essential for solid-phase peptide synthesis (SPPS). This high-purity chiral building block is critical for introducing the unique steric and electronic properties of the 3-chloro-D-phenylalanine residue into synthetic peptide chains. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research laboratories developing novel therapeutic peptides, peptidomimetics, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental building block for the automated synthesis of custom peptides.
• Pharmaceutical Research: Used in the discovery and development of novel peptide-based drugs, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Peptidomimetic Design: Incorporation of the chlorinated D-phenylalanine side chain aids in creating metabolically stable analogs with modified biological activity and receptor binding profiles.
• Chemical Biology & Proteomics: Serves as a tool for studying protein-protein interactions and enzyme mechanisms by introducing specific, non-natural residues into peptide sequences.
• Antibiotic & Antimicrobial Peptide Development: The chloro-substituent can enhance lipophilicity and membrane interaction, properties valuable in designing new antimicrobial agents.
• Material Science: Potential use in synthesizing specialized peptide-polymer conjugates or self-assembling biomaterials with tailored properties.

Basic Information

Product Name	Fmoc-3-Chloro-D-Phenylalanine
CAS No.	205526-23-4
Molecular Formula	C24H20ClNO4
Molecular Weight	421.87 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-chloro-D-phenylalanine; Fmoc-3-chloro-D-Phe-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-chlorophenyl)propanoic acid; Fmoc-D-3-Chlorophenylalanine; N-Fmoc-3-chloro-D-phenylalanine; Fmoc-3-Cl-D-Phe; Fmoc-D-3-Cl-Phe-OH
EINECS	Contact for details

Quality Control

Our Fmoc-3-Chloro-D-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the exacting standards required for advanced peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee consistent quality, lot-to-lot traceability, and compliance with research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and purity. For long-term storage, consider storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.