Description

Fmoc-D-2-Chlorophe CAS NO 205526-22-3 is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise stereochemical control and side-chain protection in complex peptide sequences. It is an essential building block for pharmaceutical R&D, particularly in the development of novel therapeutic peptides, peptidomimetics, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the controlled assembly of peptide chains.
• Pharmaceutical Intermediates: Serves as a crucial chiral synthon in the production of active pharmaceutical ingredients (APIs) for targeted therapies.
• Peptidomimetic Drug Design: Used to incorporate chlorinated phenylalanine analogs, which can enhance metabolic stability and receptor binding affinity in drug candidates.
• Bioconjugation and Labeling: Facilitates the site-specific introduction of functional handles or probes into peptides for diagnostic and research applications.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Academic and Industrial Research: A fundamental reagent for studying protein structure-function relationships and enzyme-substrate interactions.

Basic Information

Product Name	Fmoc-D-2-Chlorophe CAS NO 205526-22-3
CAS No.	205526-22-3
Molecular Formula	C24H20ClNO4
Molecular Weight	421.87 g/mol
Synonyms	Fmoc-D-2-chlorophenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-2-chlorophenylalanine; Fmoc-D-2-Cl-Phe-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-chlorophenyl)propanoic acid; N-α-Fmoc-D-2-chlorophenylalanine; Fmoc-D-(2-Cl)Phe; D-2-Chloro-Fmoc-phenylalanine; Fmoc-D-2-chloro-Phe
EINECS	Contact for details

Quality Control

Every batch of Fmoc-D-2-Chlorophe is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We guarantee high chemical and chiral purity to meet the exacting standards of pharmaceutical research and GMP-grade production. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥98% by HPLC), and specific optical rotation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	-10.0° to -15.0° (c=1, DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.