Description

Fmoc-D, L-Phg(4-Ch2Nhboc) CAS NO 205049-68-9 is a protected amino acid derivative, specifically an Fmoc-protected racemic phenylglycine analog with a side-chain Boc-protected amine group. This compound is a critical high-purity building block for solid-phase peptide synthesis (SPPS), enabling the precise incorporation of modified amino acids into complex peptide sequences. It is essential for researchers and manufacturers in pharmaceutical R&D and biotechnology developing novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex and modified peptides.
• Pharmaceutical Research: Building block for the development of peptide drug candidates, including those targeting GPCRs and other biological pathways.
• Peptide Library Construction: Used to introduce structural diversity and specific functional groups into combinatorial peptide libraries for screening.
• Bioconjugation: Intermediate for creating peptide-based conjugates for drug delivery systems or diagnostic probes.
• Chemical Biology Probes: Synthesis of labeled or tagged peptides used to study protein-protein interactions and enzyme activity.
• API Intermediate: Potential intermediate in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) for peptide drugs.

Basic Information

Product Name	Fmoc-D, L-Phg(4-Ch2Nhboc)
CAS No.	205049-68-9
Molecular Formula	C₂₈H₂₈N₂O₆
Molecular Weight	488.53 g/mol
Synonyms	Fmoc-4-(Boc-aminoaminomethyl)-D,L-phenylglycine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[[(1,1-dimethylethoxy)carbonyl]aminoaminomethyl]-D,L-phenylglycine; Fmoc-D,L-Phe(4-CH2NHBoc)-OH; Fmoc-(4-(Boc-amino)aminomethyl)-DL-homo-phenylalanine; Nα-Fmoc-Nδ-Boc-diaminobutyrine(D,L); Fmoc-D,L-4-(Boc-aminoaminomethyl)Phg; Boc-protected side-chain Fmoc-phenylglycine derivative
EINECS	Contact for details

Quality Control

Our Fmoc-D, L-Phg(4-Ch2Nhboc) is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and MS. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.