Description

Abz-Tbu-Gly-Tbu-Gly-Asn(Me)2-Ala-Ser-Ser-Arg-Leu-3-Nitro-Tyr-Arg-Oh CAS NO 204909-37-5 is a specialized, sequence-defined peptide derivative featuring a 2-aminobenzoic acid (Abz) fluorophore and a 3-nitrotyrosine modification. This compound is of significant value in biochemical research as a customized substrate or probe for studying protease activity, enzyme kinetics, and signal transduction pathways. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in proteomics and drug discovery.

Application

• Protease/Enzyme Substrate: Used as a specific, fluorogenic, or chromogenic substrate for characterizing the activity and inhibition of target proteases.
• Biochemical Assay Development: Serves as a critical component in high-throughput screening (HTS) assays and diagnostic test development.
• Signal Transduction Research: Employed in studies investigating phosphorylation-mimicking pathways via its nitrotyrosine moiety.
• Peptide-Based Drug Discovery: Acts as a lead compound or intermediate for developing novel therapeutic agents targeting specific enzymatic processes.
• Academic Research: Utilized in university and institutional labs for fundamental studies in biochemistry, molecular biology, and medicinal chemistry.
• Quality Control Reference Standard: Functions as a certified reference material (CRM) for analytical method validation in peptide manufacturing.

Basic Information

Item	Details
Product Name	Abz-Tbu-Gly-Tbu-Gly-Asn(Me)2-Ala-Ser-Ser-Arg-Leu-3-Nitro-Tyr-Arg-Oh
CAS No.	204909-37-5
Molecular Formula	C68H108N22O22
Molecular Weight	1561.7 g/mol (Contact for details)
Synonyms	2-Aminobenzoyl-Tbu-Gly-Tbu-Gly-Asn(Me)2-Ala-Ser-Ser-Arg-Leu-3-Nitro-Tyr-Arg-OH; Abz-Thz-Gly-Thz-Gly-Asn(Me)2-Ala-Ser-Ser-Arg-Leu-Tyr(3-NO2)-Arg-OH; Custom Protease Substrate Peptide 204909-37-5; Fluorogenic Peptide Substrate; 3-Nitrotyrosine-containing Peptide; Abz-labeled Peptide; Research Peptide 204909-37-5
EINECS	Contact for details

Quality Control

Our Abz-Tbu-Gly-Tbu-Gly-Asn(Me)2-Ala-Ser-Ser-Arg-Leu-3-Nitro-Tyr-Arg-Oh is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and MS for identity confirmation, to ensure compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment to guarantee traceability and consistency for your research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.