Description

Fmoc-D, L-Phe(4-Ch2Nh-Boc) is a protected amino acid derivative, specifically a side-chain modified phenylalanine analog, used as a key building block in solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over peptide sequence and structure, enabling the incorporation of unique functional handles for further bioconjugation or labeling. It is essential for the development of complex peptides, peptidomimetics, and bioconjugates in pharmaceutical research and advanced material science.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block (Fmoc-amino acid) for the automated or manual synthesis of custom peptide sequences.
• Pharmaceutical Research & Development: Used in the discovery and production of therapeutic peptides, peptide hormones, and targeted drug candidates.
• Bioconjugation and Labeling: The protected amine group (Ch2Nh-Boc) on the phenylalanine side chain serves as a specific site for attaching fluorescent dyes, affinity tags (e.g., biotin), or other functional molecules.
• Peptidomimetic Design: Enables the creation of modified peptides with enhanced stability, bioavailability, or specific biological activity.
• Combinatorial Chemistry Libraries: A valuable reagent for generating diverse libraries of peptide-based compounds for high-throughput screening.
• Academic & Industrial Research: Supports fundamental studies in biochemistry, chemical biology, and medicinal chemistry.

Basic Information

Product Name	Fmoc-D, L-Phe(4-Ch2Nh-Boc)
CAS No.	204715-91-3
Molecular Formula	C₃₁H₃₄N₂O₆
Molecular Weight	530.61 g/mol
Synonyms	Fmoc-DL-Phe(4-NH-Boc); N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[[(1,1-dimethylethoxy)carbonyl]amino]-D,L-phenylalanine; Fmoc-4-(Boc-amino)-D,L-phenylalanine; Fmoc-Phe(4-NHBoc)-OH (racemic); N-α-Fmoc-N-ε-Boc-Lysine analog (phenylalanine-based); (RS)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-((tert-butoxycarbonyl)amino)phenyl)propanoic acid; Fmoc-DL-4-(Boc-amino)phenylalanine; Boc-protected Fmoc-phenylalanine derivative.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical applications. Each batch is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	Racemic mixture (DL)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.